Lubricant is a general term for auxiliary materials that are added to the tablet material before finger pressing to make it have or increase fluidity, adhesion resistance and lubricity, so as to facilitate the tablet pressing process.According to their mechanism of action, lubricants can be divided into three kinds;Lubricant refers to the auxiliary material that can reduce the friction between the particle or tablet and the die.After the tablet die is cleaned, a layer of dimethyl silicone oil can also solve the problem of sticking and punching for some varieties.
1. Slow release aspirin tablets
Take aspirin powder 1000g(crystal diameter is 0.1770mm), ethoxy ethyl cellulose (containing ethoxy 12%)70g, dissolved in 300ml(1:1) toluene - methylene chloride solution and methylsilicone oil 30g toluene solution, starch 400g, glycerol palmitate hard fatty acid ester 300g, talcum powder 50g, Micrystalline cellulose 100g, which can be obtained by normal method.
2. Compound acetaminophen capsule
Aspirin particles were heated to 50℃, coated with a 1:1 copolymer of methacrylate and methacrylate and 0.045%AF emulsion (antifoaming agent), dried at 37.8℃ in a boiling drying bed for more than 24h, and then weighed 52.144g, Add sodium lauryl sulfate 0.203g, paracetamol 41.45g, dimethyl silicone oil 0.363g, polyoxyethylene dehydrated monoleate 0.145g and mix well, then load into capsule to get.The capsule weighed 700mg, and each capsule contained 325mg aspirin and paracetamol.
3. Ibuprofen sustained-release tablets
Ibuprofen 58.25%, lactose 14.50%, calcium hydrogen phosphate 12.60%, glyceryl behenate 11.65%, magnesium stearate 1.0%, talcum powder + silicone oil (4:1)2.0% were prepared into tablets.
The solid preparations mentioned above are actually common drugs used in our daily life.The use of silicone oil can not be underestimated, but silicone oil also divided into industrial dimethyl silicone oil and dimethyl silicone oil, there are great differences in composition, quality inspection, so the selection of medicinal dimethyl silicone oil must pay attention to distinguish.
